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The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells
BACKGROUND: We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb complex. Here, we analyzed the anti-viral function of CIITA in myeloid cells, anot...
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| Pubblicato in: | J Transl Med |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4835826/ https://ncbi.nlm.nih.gov/pubmed/27089879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0853-5 |
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