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The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

The activation of CD4(+) T helper cells is strictly dependent on the presentation of antigenic peptides by MHC class II (MHC-II) molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (class II transactivator). Thus, CIITA plays a pivotal rol...

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Bibliografiske detaljer
Main Authors: Forlani, Greta, Abdallah, Rawan, Accolla, Roberto S., Tosi, Giovanna
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749491/
https://ncbi.nlm.nih.gov/pubmed/23986750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2013.00234
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