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The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein

Human T cell lymphotropic virus type 1 (HTLV-1) Tax-1, a key protein in HTLV-1-induced T cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB pathway is constitutively activated by Tax-1, which binds to NF-κB proteins and activates the IκB kinase (IKK). Upon phosph...

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Pubblicato in:J Virol
Autori principali: Forlani, Greta, Abdallah, Rawan, Accolla, Roberto S., Tosi, Giovanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794681/
https://ncbi.nlm.nih.gov/pubmed/26792751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03000-15
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