Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk

Therapeutic interventions that lower LDL-cholesterol effectively reduce the risk of coronary artery disease (CAD). However, statins, the most widely prescribed LDL-cholesterol lowering drugs, increase diabetes risk. We used genome-wide association study (GWAS) data in the public domain to investigat...

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Veröffentlicht in:Hum Genet
Hauptverfasser: Tragante, Vinicius, Asselbergs, Folkert W., Swerdlow, Daniel I., Palmer, Tom M., Moore, Jason H., de Bakker, Paul I. W., Keating, Brendan J., Holmes, Michael V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835528/
https://ncbi.nlm.nih.gov/pubmed/26946290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-016-1647-9
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