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Light-Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch
Mutants of cellular retinoic acid-binding protein II (CRABPII), engineered to bind all-trans-retinal as an iminium species, demonstrate photochromism upon irradiation with light at different wavelengths. UV light irradiation populates the cis-imine geometry, which has a high pK(a), leading to proton...
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| izdano v: | Chembiochem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4835339/ https://ncbi.nlm.nih.gov/pubmed/26684483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500613 |
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