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Light-Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch

Mutants of cellular retinoic acid-binding protein II (CRABPII), engineered to bind all-trans-retinal as an iminium species, demonstrate photochromism upon irradiation with light at different wavelengths. UV light irradiation populates the cis-imine geometry, which has a high pK(a), leading to proton...

詳細記述

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書誌詳細
出版年:Chembiochem
主要な著者: Berbasova, Tetyana, Santos, Elizabeth M., Nosrati, Meisam, Vasileiou, Chrysoula, Geiger, James H., Borhan, Babak
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835339/
https://ncbi.nlm.nih.gov/pubmed/26684483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500613
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