Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age-Related Osteoporosis

Age-related osteoporosis is driven by defects in the tissue-resident mesenchymal stromal cells (MSCs), a heterogeneous population of musculoskeletal progenitors that includes skeletal stem cells. MSC decline leads to reduced bone formation, causing loss of bone volume and the breakdown of bony micro...

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Udgivet i:Stem Cells Transl Med
Main Authors: Kiernan, Jeffrey, Hu, Sally, Grynpas, Marc D., Davies, John E., Stanford, William L.
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2016
Fag:
Tissue Engineering and Regenerative Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835247/
https://ncbi.nlm.nih.gov/pubmed/26987353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0231
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