Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells

Lysosomal membrane permeabilization (LMP) induced by oxidative stress has recently emerged as a prominent mechanism behind TNF cytotoxicity. This pathway relies on diffusion of hydrogen peroxide into lysosomes containing redox-active iron, accumulated by breakdown of iron-containing proteins and sub...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Ullio, Chiara, Brunk, Ulf T, Urani, Chiara, Melchioretto, Pasquale, Bonelli, Gabriella, Baccino, Francesco M, Autelli, Riccardo
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
Materias:
Basic Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835206/
https://ncbi.nlm.nih.gov/pubmed/26566051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1106662
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