High Risk of Colorectal and Endometrial Cancer in Ashkenazi families with the MSH2 A636P founder mutation

BACKGROUND & AIMS: The MSH2 A636P mutation is a founder mutation in Ashkenazi Jews that causes Lynch syndrome with a prevalence of 0.4%–0.7%. Estimates of age-specific cumulative risk and lifetime risk for colorectal cancer (CRC) and endometrial cancer (EC) specific to carriers of this mutation...

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Publicado no:Gastroenterology
Main Authors: Mukherjee, Bhramar, Rennert, Gad, Ahn, Jaeil, Dishon, Sara, Lejbkowicz, Flavio, Rennert, Hedy, Shiovitz, Stacey, Moreno, Victor, Gruber, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835182/
https://ncbi.nlm.nih.gov/pubmed/21419771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.071
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