Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene

We have developed retroviral replicating vectors (RRV) derived from Moloney murine gammaretrovirus with an amphotropic envelope and an encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES)-transgene cassette downstream of the env gene. During long-term (180 days) replication of the v...

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Bibliografske podrobnosti
izdano v:Hum Gene Ther Methods
Main Authors: Lin, Amy H., Liu, Yanzheng, Burrascano, Cynthia, Cunanan, Kathrina, Logg, Christopher R., Robbins, Joan M., Kasahara, Noriyuki, Gruber, Harry, Ibañez, Carlos, Jolly, Douglas J.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834527/
https://ncbi.nlm.nih.gov/pubmed/26918465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2015.131
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