A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo

Preclinical development of RNA interference (RNAi)-based therapeutics requires a rapid, accurate, and robust method of simultaneously quantifying mRNA knockdown in hundreds of samples. The most well-established method to achieve this is quantitative real-time polymerase chain reaction (qRT-PCR), a l...

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Publicat a:Nucleic Acid Ther
Autors principals: Coles, Andrew H., Osborn, Maire F., Alterman, Julia F., Turanov, Anton A., Godinho, Bruno M.D.C., Kennington, Lori, Chase, Kathryn, Aronin, Neil, Khvorova, Anastasia
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2016
Matèries:
Methods
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834514/
https://ncbi.nlm.nih.gov/pubmed/26595721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2015.0578
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