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KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis

The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. Previous studies showed that KLF4 is a tumor suppressor in the intestinal tract and plays an important role in DNA damage-repair mechanisms. Here the in vivo effects of Klf4 deletion...

詳細記述

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書誌詳細
出版年:Mol Cancer Res
主要な著者: Ghaleb, Amr M., Elkarim, Enas A., Bialkowska, Agnieszka B., Yang, Vincent W.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834227/
https://ncbi.nlm.nih.gov/pubmed/26839262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0410
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