Genetic Deletion of Klf4 in the Mouse Intestinal Epithelium Ameliorates Dextran Sodium Sulfate–induced Colitis by Modulating the NF-κB Pathway Inflammatory Response

BACKGROUND: Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor expressed in the differentiated epithelial cells lining of the intestine. Under physiological conditions, KLF4 inhibits cell proliferation. Conversely, KLF4 mediates proinflammatory signaling in macrophages and its overex...

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Hauptverfasser: Ghaleb, Amr M., Laroui, Hamed, Merlin, Didier, Yang, Vincent W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091934/
https://ncbi.nlm.nih.gov/pubmed/24681655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000022
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