A new approach to evaluating carcinogenic risk.
Carcinogenic risk assessments are based on extrapolating from high-dose chronic rodent-feeding studies to human-exposure levels. A serious problem is that about half of all substances tested at their respective maximum tolerated dose (MTD) are found to induce cancer. The MTD as currently defined has...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48341/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1736302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.3.860 |
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