Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

Conventional generation of stem cells from human blastocysts produces a developmentally advanced, or primed, stage of pluripotency. In vitro resetting to a more naive phenotype has been reported. However, whether the reset culture conditions of selective kinase inhibition can enable capture of naive...

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Pubblicato in:Stem Cell Reports
Autori principali: Guo, Ge, von Meyenn, Ferdinand, Santos, Fatima, Chen, Yaoyao, Reik, Wolf, Bertone, Paul, Smith, Austin, Nichols, Jennifer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834040/
https://ncbi.nlm.nih.gov/pubmed/26947977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.02.005
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