Identification of Mediator kinase substrates in human cells using cortistatin A and quantitative phosphoproteomics

Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116). We identified over 16,000 quantified phosphosites including 78 high-confidence Mediator kinase target...

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Publicado no:Cell Rep
Main Authors: Poss, Zachary C., Ebmeier, Christopher C., Odell, Aaron T., Tangpeerachaikul, Anupong, Lee, Thomas, Pelish, Henry E., Shair, Matthew D., Dowell, Robin D., Old, William M., Taatjes, Dylan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833653/
https://ncbi.nlm.nih.gov/pubmed/27050516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.030
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