The Necrosome Promotes Pancreas Oncogenesis via CXCL1 and Mincle Induced Immune Suppression

Neoplastic pancreatic epithelial cells are widely believed to die via Caspase 8-dependant apoptotic cell death and chemotherapy is thought to further promote tumor apoptosis(1). Conversely, disruption of apoptosis is a basic modality cancer cells exploit for survival(2,3). However, the role of necro...

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Veröffentlicht in:Nature
Hauptverfasser: Seifert, Lena, Werba, Gregor, Tiwari, Shaun, Giao Ly, Nancy Ngoc, Alothman, Sara, Alqunaibit, Dalia, Avanzi, Antonina, Barilla, Rocky, Daley, Donnele, Greco, Stephanie H., Torres-Hernandez, Alejandro, Pergamo, Matthew, Ochi, Atsuo, Zambirinis, Constantinos P., Pansari, Mridul, Rendon, Mauricio, Tippens, Daniel, Hundeyin, Mautin, Mani, Vishnu R., Hajdu, Cristina, Engle, Dannielle, Miller, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833566/
https://ncbi.nlm.nih.gov/pubmed/27049944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17403
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