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PTHrP Interacts With the TGF-β/BMP-2/Gremlin Signaling Pathway to Regulate Pro-inflammatory and Pro-fibrotic Mediators in Pancreatic Acinar and Stellate Cells
OBJECTIVES: TGF-β regulates immune and fibrotic responses of chronic pancreatitis (CP). The bone morphogenetic protein-2 (BMP-2) antagonist gremlin is regulated by TGF-β. Parathyroid hormone-related hormone (PTHrP) levels are elevated in CP. Here we investigated the crosstalk between TGF-β/BMP-2/gre...
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| Veröffentlicht in: | Pancreas |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833530/ https://ncbi.nlm.nih.gov/pubmed/26495794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000522 |
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