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PTHrP Interacts With the TGF-β/BMP-2/Gremlin Signaling Pathway to Regulate Pro-inflammatory and Pro-fibrotic Mediators in Pancreatic Acinar and Stellate Cells

OBJECTIVES: TGF-β regulates immune and fibrotic responses of chronic pancreatitis (CP). The bone morphogenetic protein-2 (BMP-2) antagonist gremlin is regulated by TGF-β. Parathyroid hormone-related hormone (PTHrP) levels are elevated in CP. Here we investigated the crosstalk between TGF-β/BMP-2/gre...

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Vydáno v:Pancreas
Hlavní autoři: Bhatia, Vandanajay, Cao, Yanna, Ko, Tien C., Falzon, Miriam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833530/
https://ncbi.nlm.nih.gov/pubmed/26495794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000522
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