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Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding

The immunosuppressive drug cyclosporin A (CsA) binds to its receptor protein cyclophilin 18 (Cyp18) in two distinct kinetic phases, while the mechanism remains elusive. Stopped-flow measurements coupled with titration and competition experiments were used to investigate the puzzling two-phase proces...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Lin, Weilin, Quintero, Andres, Zhang, Yixin
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833397/
https://ncbi.nlm.nih.gov/pubmed/27082870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153669
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