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Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding
The immunosuppressive drug cyclosporin A (CsA) binds to its receptor protein cyclophilin 18 (Cyp18) in two distinct kinetic phases, while the mechanism remains elusive. Stopped-flow measurements coupled with titration and competition experiments were used to investigate the puzzling two-phase proces...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833397/ https://ncbi.nlm.nih.gov/pubmed/27082870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153669 |
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