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Cytochrome c folds through foldon-dependent native-like intermediates in an ordered pathway

Previous hydrogen exchange (HX) studies of the spontaneous reversible unfolding of Cytochrome c (Cyt c) under native conditions have led to the following conclusions. Native Cyt c (104 residues) is composed of five cooperative folding units, called foldons. The high-energy landscape is dominated by...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hu, Wenbing, Kan, Zhong-Yuan, Mayne, Leland, Englander, S. Walter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833275/
https://ncbi.nlm.nih.gov/pubmed/26966231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522674113
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