Structural basis of rifampin inactivation by rifampin phosphotransferase

Rifampin (RIF) is a first-line drug used for the treatment of tuberculosis and other bacterial infections. Various RIF resistance mechanisms have been reported, and recently an RIF-inactivation enzyme, RIF phosphotransferase (RPH), was reported to phosphorylate RIF at its C21 hydroxyl at the cost of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Qi, Xiaofeng, Lin, Wei, Ma, Miaolian, Wang, Chengyuan, He, Yang, He, Nisha, Gao, Jing, Zhou, Hu, Xiao, Youli, Wang, Yong, Zhang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833264/
https://ncbi.nlm.nih.gov/pubmed/27001859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523614113
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