The pharmacokinetic and pharmacodynamic interaction of clopidogrel and cilostazol in relation to CYP2C19 and CYP3A5 genotypes

AIM: The primary objective of the present study was to evaluate the pharmacokinetic and pharmacodynamic interactions between clopidogrel and cilostazol in relation to the CYP2C19 and CYP3A5 genotypes. METHODS: In a randomized, three‐way crossover study, 27 healthy subjects were administered clopidog...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Kim, Ho‐Sook, Lim, Younghae, Oh, Minkyung, Ghim, Jong‐lyul, Kim, Eun‐Young, Kim, Dong‐Hyun, Shin, Jae‐Gook
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833149/
https://ncbi.nlm.nih.gov/pubmed/26426352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12794
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