Catalytic Asymmetric Reactions of 4‐Substituted Indoles with Nitroethene: A Direct Entry to Ergot Alkaloid Structures

A domino Friedel–Crafts/nitro‐Michael reaction between 4‐substituted indoles and nitroethene is presented. The reaction is catalyzed by BINOL‐derived phosphoric acid catalysts, and delivers the corresponding 3,4‐ring‐fused indoles with very good results in terms of yields and diastereo‐ and enantios...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Romanini, Simone, Galletti, Emilio, Caruana, Lorenzo, Mazzanti, Andrea, Himo, Fahmi, Santoro, Stefano, Fochi, Mariafrancesca, Bernardi, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY‐VCH Verlag 2015
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832839/
https://ncbi.nlm.nih.gov/pubmed/26486074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201502655
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