Catalytic Asymmetric Reactions of 4‐Substituted Indoles with Nitroethene: A Direct Entry to Ergot Alkaloid Structures

A domino Friedel–Crafts/nitro‐Michael reaction between 4‐substituted indoles and nitroethene is presented. The reaction is catalyzed by BINOL‐derived phosphoric acid catalysts, and delivers the corresponding 3,4‐ring‐fused indoles with very good results in terms of yields and diastereo‐ and enantios...

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Bibliografiske detaljer
Udgivet i:Chemistry
Main Authors: Romanini, Simone, Galletti, Emilio, Caruana, Lorenzo, Mazzanti, Andrea, Himo, Fahmi, Santoro, Stefano, Fochi, Mariafrancesca, Bernardi, Luca
Format: Artigo
Sprog:Inglês
Udgivet: WILEY‐VCH Verlag 2015
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832839/
https://ncbi.nlm.nih.gov/pubmed/26486074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201502655
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