The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone...

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Publicat a:Cell Metab
Autors principals: He, Baokun, Nohara, Kazunari, Park, Noheon, Park, Yong-Sung, Guillory, Bobby, Zhao, Zhaoyang, Garcia, Jose M., Koike, Nobuya, Lee, Cheng Chi, Takahashi, Joseph S., Yoo, Seung-Hee, Chen, Zheng
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832569/
https://ncbi.nlm.nih.gov/pubmed/27076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.03.007
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