The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: He, Baokun, Nohara, Kazunari, Park, Noheon, Park, Yong-Sung, Guillory, Bobby, Zhao, Zhaoyang, Garcia, Jose M., Koike, Nobuya, Lee, Cheng Chi, Takahashi, Joseph S., Yoo, Seung-Hee, Chen, Zheng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832569/
https://ncbi.nlm.nih.gov/pubmed/27076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.03.007
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