The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Metab
Main Authors: He, Baokun, Nohara, Kazunari, Park, Noheon, Park, Yong-Sung, Guillory, Bobby, Zhao, Zhaoyang, Garcia, Jose M., Koike, Nobuya, Lee, Cheng Chi, Takahashi, Joseph S., Yoo, Seung-Hee, Chen, Zheng
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832569/
https://ncbi.nlm.nih.gov/pubmed/27076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.03.007
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker