The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: He, Baokun, Nohara, Kazunari, Park, Noheon, Park, Yong-Sung, Guillory, Bobby, Zhao, Zhaoyang, Garcia, Jose M., Koike, Nobuya, Lee, Cheng Chi, Takahashi, Joseph S., Yoo, Seung-Hee, Chen, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832569/
https://ncbi.nlm.nih.gov/pubmed/27076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.03.007
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