Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model

OBJECTIVE: To explore whether aberrant transient chondrocyte behaviors occur in the joints of STR/Ort mice (which spontaneously develop osteoarthritis [OA]) and whether they are attributable to an endochondral growth defect. METHODS: Knee joints from STR/Ort mice with advanced OA and age‐matched CBA...

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Publicado en:Arthritis Rheumatol
Autores principales: Staines, K. A., Madi, K., Mirczuk, S. M., Parker, S., Burleigh, A., Poulet, B., Hopkinson, M., Bodey, A. J., Fowkes, R. C., Farquharson, C., Lee, P. D., Pitsillides, A. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Osteoarthritis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832379/
https://ncbi.nlm.nih.gov/pubmed/26605758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39508
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