Using Zinc Finger Nuclease Technology to Generate CRX‐Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation

The purpose of this study was to generate human embryonic stem cell (hESC) lines harboring the green fluorescent protein (GFP) reporter at the endogenous loci of the Cone‐Rod Homeobox (CRX) gene, a key transcription factor in retinal development. Zinc finger nucleases (ZFNs) designed to cleave in th...

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Vydáno v:Stem Cells
Hlavní autoři: Collin, Joseph, Mellough, Carla B, Dorgau, Birthe, Przyborski, Stefan, Moreno‐Gimeno, Inmaculada, Lako, Majlinda
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832345/
https://ncbi.nlm.nih.gov/pubmed/26608863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2240
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