Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

OBJECTIVE: In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Spengler, Julia, Lugonja, Božo, Jimmy Ytterberg, A., Zubarev, Roman A., Creese, Andrew J., Pearson, Mark J., Grant, Melissa M., Milward, Michael, Lundberg, Karin, Buckley, Christopher D., Filer, Andrew, Raza, Karim, Cooper, Paul R., Chapple, Iain L., Scheel‐Toellner, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Rheumatoid Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832324/
https://ncbi.nlm.nih.gov/pubmed/26245941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39313
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