Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

OBJECTIVE: In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease...

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Udgivet i:Arthritis Rheumatol
Main Authors: Spengler, Julia, Lugonja, Božo, Jimmy Ytterberg, A., Zubarev, Roman A., Creese, Andrew J., Pearson, Mark J., Grant, Melissa M., Milward, Michael, Lundberg, Karin, Buckley, Christopher D., Filer, Andrew, Raza, Karim, Cooper, Paul R., Chapple, Iain L., Scheel‐Toellner, Dagmar
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Rheumatoid Arthritis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832324/
https://ncbi.nlm.nih.gov/pubmed/26245941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39313
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