HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors

The frequent development of drug resistance to targeted therapies in cancer patients has stimulated interest in strategies counteracting resistance. Combining immunotherapies with targeted therapies is one such strategy. In this context, we asked whether human NK cells can target melanoma cells that...

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Veröffentlicht in:Eur J Immunol
Hauptverfasser: Sottile, Rosa, Pangigadde, Pradeepa N., Tan, Thomas, Anichini, Andrea, Sabbatino, Francesco, Trecroci, Francesca, Favoino, Elvira, Orgiano, Laura, Roberts, James, Ferrone, Soldano, Kärre, Klas, Colucci, Francesco, Carbone, Ennio
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Immunomodulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832274/
https://ncbi.nlm.nih.gov/pubmed/26564811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445289
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