Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

Factor H (FH) binds apoptotic cells to limit the inflammatory potential of complement. Here we report that FH is actively internalized by apoptotic cells to enhance cathepsin L-mediated cleavage of endogenously expressed C3, which results in increased surface opsonization with iC3b. In addition, int...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Martin, M, Leffler, J, Smoląg, K I, Mytych, J, Björk, A, Chaves, L D, Alexander, J J, Quigg, R J, Blom, A M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832108/
https://ncbi.nlm.nih.gov/pubmed/26768663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.164
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