A Role for Diminished GABA Transporter Activity in the Cortical Discharge Phenotype of MeCP2-Deficient Mice

Cortical network hyper-excitability is a common phenotype in mouse models lacking the transcriptional regulator methyl-CPG-binding protein 2 (MeCP2). Here, we implicate enhanced GABA(B) receptor activity stemming from diminished cortical expression of the GABA transporter GAT-1 in the genesis of thi...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Zhang, Liang, Wither, Robert G, Lang, Min, Wu, Chiping, Sidorova-Darmos, Elena, Netchev, Hristo, Matolcsy, Catherine B, Snead, Orlando Carter, Eubanks, James H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832024/
https://ncbi.nlm.nih.gov/pubmed/26499511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.323
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