Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study

Varenicline, a nicotinic partial agonist, is the most effective treatment for tobacco use disorder. However, its mechanism of action is still unclear and may involve stimulating dopaminergic transmission. Here we used PET imaging with [(11)C]-(+)-PHNO to explore for the first time the impact of vare...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Di Ciano, Patricia, Guranda, Mihail, Lagzdins, Dina, Tyndale, Rachel F, Gamaleddin, Islam, Selby, Peter, Boileau, Isabelle, Le Foll, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832011/
https://ncbi.nlm.nih.gov/pubmed/26442600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.305
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