A DNA polymerase alpha pause site is a hot spot for nucleotide misinsertion.
In this study we examined whether the arrest of DNA polymerase alpha (pol alpha)-catalyzed DNA synthesis at template pause sites entails terminal nucleotide misincorporation. An approach was developed to identify the 3'-terminal nucleotide in nascent DNA chains that accumulate at pause sites. A radi...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1992
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1731352/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.2.763 |
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