Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis

The Rho-family GTPase Cdc42 regulates cell polarity and localizes to the cell division site. Cdc42 is activated by guanine nucleotide exchange factors (GEFs). We report that Cdc42 promotes cytokinesis via a unique spatiotemporal activation pattern due to the distinct action of its GEFs, Gef1 and Scd...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Wei, Bin, Hercyk, Brian S., Mattson, Nicholas, Mohammadi, Ahmad, Rich, Julie, DeBruyne, Erica, Clark, Mikayla M., Das, Maitreyi
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831878/
https://ncbi.nlm.nih.gov/pubmed/26941334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0700
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