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Increased Smad2/3 Phosphorylation in Circulating Leukocytes and Platelet-Leukocyte Aggregates in a Mouse Model of Aortic Valve Stenosis: Evidence of Systemic Activation of Platelet-Derived TGF-β1 and Correlation with Cardiac Dysfunction

BACKGROUND: Transforming growth factor-β1 (TGF-β1) has been implicated in the pathogenesis of aortic valve stenosis (AS). There is, however, little direct evidence for a role of active TGF-β1 in AS due to the sensitivity of current assays. We searched for evidence of plasma TGF-β1 activation by assa...

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Detalhes bibliográficos
Publicado no:Blood Cells Mol Dis
Main Authors: Wang, Wei, Burg, Nathalie, Vootukuri, Spandana, Barry, Coller S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831072/
https://ncbi.nlm.nih.gov/pubmed/27067480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2016.01.007
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