Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide. Large interindividual variation in susceptibility toward APAP-induced liver failure has been reported. However, the exact underlying factors causing this variabil...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Jetten, Marlon J. A., Ruiz-Aracama, Ainhoa, Coonen, Maarten L. J., Claessen, Sandra M., van Herwijnen, Marcel H. M., Lommen, Arjen, van Delft, Joost H. M., Peijnenburg, Ad A. C. M., Kleinjans, Jos C. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Toxicogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830893/
https://ncbi.nlm.nih.gov/pubmed/26104854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1545-2
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