Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2

Therapeutic intervention aimed at reactivation of fetal hemoglobin protein (HbF) is a promising approach for ameliorating sickle cell disease (SCD) and β-thalassemia. Previous studies showed genetic knockdown of histone deacetylase (HDAC) 1 or 2 is sufficient to induce HbF. Here we show that ACY-957...

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Publicado en:PLoS One
Main Authors: Shearstone, Jeffrey R., Golonzhka, Olga, Chonkar, Apurva, Tamang, David, van Duzer, John H., Jones, Simon S., Jarpe, Matthew B.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830539/
https://ncbi.nlm.nih.gov/pubmed/27073918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153767
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