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Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones
A novel synthetic route to 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidine-2,4-diones, of interest for potential antitumor activity, is reported. The route uses 1,3-disubstituted 6-amino uracils as starting materials. The key step is a hydrazine-induced cyclization reaction to form the fused pyri...
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| Udgivet i: | Tetrahedron Lett |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4829973/ https://ncbi.nlm.nih.gov/pubmed/27087706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.02.051 |
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