Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents

A series of 2,5,7-trisubstituted pyrimido[4,5-d]pyrimidine cyclin-dependent kinase (CDK2) inhibitors is designed and synthesized. 6-Amino-2-thiouracil is reacted with an aldehyde and thiourea to prepare the pyrimido[4,5-d]-pyrimidines. Alkylation and amination of the latter ones give different amino...

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Bibliografiske detaljer
Main Authors: El-Moghazy, Samir M., Ibrahim, Diaa A., Abdelgawad, Nagwa M., Farag, Nahla A. H., El-Khouly, Ahmad S.
Format: Artigo
Sprog:Inglês
Udgivet: Österreichische Apotheker-Verlagsgesellschaft 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163380/
https://ncbi.nlm.nih.gov/pubmed/21886895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1103-16
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