The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein

The 37/67 kDa laminin receptor (LR) is a non-integrin protein, which binds both laminin-1 of the extracellular matrix and prion proteins, that hold a central role in prion diseases. The 37/67 kDa LR has been identified as interactor for the prion protein (PrP(C)) and to be required for pathological...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sarnataro, Daniela, Pepe, Anna, Altamura, Gennaro, De Simone, Imma, Pesapane, Ada, Nitsch, Lucio, Montuori, Nunzia, Lavecchia, Antonio, Zurzolo, Chiara
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829897/
https://ncbi.nlm.nih.gov/pubmed/27071549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24457
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