GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

Cancer-associated fibroblasts (CAFs) contribute to the malignant aggressiveness through secreted factors like IL1β, which may drive pro-tumorigenic inflammatory phenotypes mainly acting via the cognate receptor named IL1R1. Here, we demonstrate that signalling mediated by the G protein estrogen rece...

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Pubblicato in:Sci Rep
Autori principali: De Marco, Paola, Lappano, Rosamaria, Francesco, Ernestina Marianna De, Cirillo, Francesca, Pupo, Marco, Avino, Silvia, Vivacqua, Adele, Abonante, Sergio, Picard, Didier, Maggiolini, Marcello
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829876/
https://ncbi.nlm.nih.gov/pubmed/27072893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24354
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