Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room

Glutathione (GSH) is the most abundant low-molecular-mass thiol within cells and one of the major antioxidant compounds in body fluids. Under pro-oxidant conditions, two GSH molecules donate one electron each and are converted into glutathione disulfide (GSSG). The GSH/GSSG molar ratio is considered...

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Veröffentlicht in:J Chromatogr B Analyt Technol Biomed Life Sci
Hauptverfasser: Giustarini, Daniela, Tsikas, Dimitrios, Colombo, Graziano, Milzani, Aldo, Dalle-Donne, Isabella, Fanti, Paolo, Rossi, Ranieri
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829456/
https://ncbi.nlm.nih.gov/pubmed/26905452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.02.015
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