Medulloblastoma genotype dictates blood brain barrier phenotype

The childhood brain tumour medulloblastoma includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant Beta-Catenin in WNT-medulloblastoma – an essentially curable form of the disease – induce an aberrant fenestrated vasculature that permits the accumu...

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Udgivet i:Cancer Cell
Main Authors: Phoenix, Timothy N., Patmore, Deanna M., Boop, Scott, Boulos, Nidal, Jacus, Megan O., Patel, Yogesh T., Roussel, Martine F, Finkelstein, David, Goumnerova, Lilian, Perreault, Sebastien, Wadhwa, Elizabeth, Cho, Yoon-Jae, Stewart, Clinton F., Gilbertson, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829447/
https://ncbi.nlm.nih.gov/pubmed/27050100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.03.002
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