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Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons

The rostral ventromedial medulla (RVM) exerts both inhibitory and excitatory controls over nociceptive neurons in the spinal cord and medullary dorsal horn. Selective ablation of mu-opioid receptor (MOR)-expressing neurons in the RVM using saporin conjugated to the MOR agonist dermorphin–saporin (de...

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Publicado en:Pain
Main Authors: Harasawa, Ichiro, Johansen, Joshua P., Fields, Howard L., Porreca, Frank, Meng, Ian D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829402/
https://ncbi.nlm.nih.gov/pubmed/26335909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000344
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