GWAS in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture

OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. Our aim was to perform the first genome-wide association study on individuals from the Americas enriched for Native American heritage. MATERIALS AND METHODS: We analyzed 3,710 individuals...

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izdano v:Arthritis Rheumatol
Main Authors: Alarcón-Riquelme, Marta E., Ziegler, Julie T., Molineros, Julio, Howard, Timothy D., Moreno-Estrada, Andrés, Sánchez-Rodríguez, Elena, Ainsworth, Hannah C., Ortiz-Tello, Patricia, Comeau, Mary E., Rasmussen, Astrid, Kelly, Jennifer A., Adler, Adam, Acevedo-Vázquez, Eduardo, Cucho, Jorge Mariano, García-De la Torre, Ignacio, Cardiel, Mario H., Miranda, Pedro, Catoggio, Luis, Maradiaga-Ceceña, Marco, Gaffney, Patrick, Vyse, Timothy, Criswell, Lindsey A., Tsao, Betty P., Sivils, Kathy L., Bae, Sang-Cheol, James, Judith A., Kimberly, Robert, Kaufman, Ken, Harley, John B., Esquivel-Valerio, Jorge, Moctezuma, José F., García, Mercedes A., Berbotto, Guillermo, Babini, Alejandra, Scherbarth, Hugo, Toloza, Sergio, Baca, Vicente, Nath, Swapan K., Salinas, Carlos Aguilar, Orozco, Lorena, Tusié-Luna, Teresa, Zidovetzki, Raphael, Pons-Estel, Bernardo A., Langefeld, Carl D., Jacob, Chaim O.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829354/
https://ncbi.nlm.nih.gov/pubmed/26606652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39504
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