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ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo
Adenosine deaminases bind double stranded RNA and convert adenosine to inosine. Editing creates multiple isoforms of neurotransmitter receptors, such as with Gria2. Adar2 KO mice die of seizures shortly after birth, but if the Gria2 Q/R editing site is mutated to mimic the edited version then the an...
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| Publicado no: | RNA Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4829308/ https://ncbi.nlm.nih.gov/pubmed/26669816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1110675 |
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