ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo

Adenosine deaminases bind double stranded RNA and convert adenosine to inosine. Editing creates multiple isoforms of neurotransmitter receptors, such as with Gria2. Adar2 KO mice die of seizures shortly after birth, but if the Gria2 Q/R editing site is mutated to mimic the edited version then the an...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:RNA Biol
Päätekijät: Dillman, Allissa A., Cookson, Mark R., Galter, Dagmar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2015
Aiheet:
Brief Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829308/
https://ncbi.nlm.nih.gov/pubmed/26669816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1110675
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