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Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation

Allopurinol and its active metabolite, oxypurinol are widely used in the treatment of gout and hyperuricemia. They inhibit xanthine oxidase (XO) an enzyme in the purine degradation pathway that converts xanthine to uric acid. This investigation examined the effect of allopurinol and oxypurinol on bo...

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Detalhes bibliográficos
Publicado no:Exp Cell Res
Main Authors: Orriss, Isabel R., Arnett, Timothy R., George, Jacob, Witham, Miles D.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829071/
https://ncbi.nlm.nih.gov/pubmed/26968635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2016.03.004
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