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Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion

Activation of the WASF3 protein by extracellular stimuli promotes actin cytoskeleton reorganization and facilitates cancer cell invasion, whereas WASF3 depletion suppresses invasion and metastasis. In quiescent cells, the interaction between WASF3 and a complex of proteins including CYFIP1 acts as a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Res
Hauptverfasser: Teng, Yong, Bahassan, Abdulaziz, Dong, Dayong, Hanold, Laura E, Ren, Xiaoou, Kennedy, Eileen J, Cowell, John K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828974/
https://ncbi.nlm.nih.gov/pubmed/26676744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1680
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