Expression of human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice

A non-coding hexanucleotide repeat expansion in the C9ORF72 gene is the most common mutation associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Patients harboring this expansion develop several unique histopathological hallmarks, including intranuclear fo...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Neuron
Auteurs principaux: Peters, Owen M., Cabrera, Gabriela Toro, Tran, Helene, Gendron, Tania F., McKeon, Jeanne E., Metterville, Jake, Weiss, Alexandra, Wightman, Nicholas, Salameh, Johnny, Kim, Juyhun, Sun, Huaming, Boylan, Kevin B., Dickson, Dennis, Kennedy, Zack, Lin, Ziqiang, Zhang, Yong-Jie, Daughrity, Lillian, Jung, Chris, Gao, Fen-Biao, Sapp, Peter C., Horvitz, H Robert, Bosco, Daryl A., Brown, Solange P., de Jong, Pieter, Petrucelli, Leonard, Mueller, Chris, Brown, Robert H.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828340/
https://ncbi.nlm.nih.gov/pubmed/26637797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.11.018
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires